SEASONAL DYNAMICS OF RED BLOOD PARAMETERS IN HEALTHY PEOPLE IN REGIONS WITH DIFFERENT TYPES OF CLIMATE: A META-ANALYSIS
© 2021 N.V. Kuzmenko1, 2 *, V.A. Tsyrlin1, M.G. Pliss1, 2
1Almazov
National Medical Research Centre, the Ministry of Health of the
Russian Federation,
St. Petersburg, Russia
2
Pavlov
First Saint Petersburg State Medical University, the Ministry of
Health
of the Russian Federation, St. Petersburg, Russia
* e-mail: nat.kuzmencko2011@yandex.ru
Abstract. It is known that in mammals living in climates other than tropical, hemoconcentration is usually observed in winter. The average modern person actively uses artificial lighting, heating, air conditioning, and also does not experience prolonged periods of hunger and thirst. The purpose of this work is to investigate, using a meta-analysis of publications, the seasonal dynamics of red blood parameters (hematocrit, hemoglobin, red blood cells count) in healthy human, as well as to study its dependence on gender and climate characteristics of the region. We analyzed data on the seasonal dynamics of red blood parameters in healthy people from 27 panel and 2 cross-sectional studies conducted in 26 regions of the world. The conducted meta-analysis showed that in humans, hematocrit and hemoglobin are significantly higher in winter than in summer. There was no pronounced seasonal dynamics of red blood cells count. Gender had no effect on the seasonal dynamics of red blood parameters. The meta-analysis showed that in regions with a large amplitude of circannual fluctuations in air temperature, seasonal changes in hemoglobin were maximum, and in a climate with a small difference between winter and summer temperatures, seasonal fluctuations in hemoglobin were not pronounced. Pronounced seasonal changes in hematocrit were noted in a climate in which atmospheric pressure was significantly higher in winter than in summer. In a climate in which atmospheric pressure in winter and summer did not differ significantly, seasonal changes in hematocrit were not pronounced. As a result, in modern humans, the seasonal dynamics of red blood parameters is mainly caused by circannual fluctuations in air temperature and atmospheric pressure. Our present and previous studies have shown that atmospheric pressure, along with the photoperiod and air temperature, influences seasonal changes in the functioning of the body, most likely through the mechanisms of oxygenation.
Keywords: hematocrit, hemoglobin, red blood cells, season, climate.
About the authors
KUZMENKO Nataliya Vladimirovna – Almazov National Medical Research Centre, the Ministry of Health of the Russian Federation. Russia, 197341, Saint Petersburg, Akkuratova st., 2; Pavlov First Saint Petersburg State Medical University, the Ministry of Health of the Russian Federation. Russia, 197022, Saint Petersburg, L'va Tolstogo st., 6–8. ORCID-0000-0001-6027-7325. E-mail: nat.kuzmencko2011@yandex.ru
TSYRLIN Vitaliy Alexandrovich – Almazov National Medical Research Centre, the Ministry of Health of the Russian Federation. Russia, 197341, Saint Petersburg, Akkuratova st., 2. ORCID-0000-0002-7767-8560. E-mail: tsyrlinva@mail.ru
PLISS Mikhail Genievich – Almazov National Medical Research Centre, the Ministry of Health of the Russian Federation. Russia, 197341, Saint Petersburg, Akkuratova st., 2; Pavlov First Saint Petersburg State Medical University, the Ministry of Health of the Russian Federation. Russia, 197022, Saint Petersburg, L'va Tolstogo st., 6–8. ORCID-0000-0002-1515-1616. E-mail: pliss@niiekf.ru
Cite this article as: Kuzmenko N.V., Tsyrlin V.A., Pliss M.G. Seasonal dynamics of red blood parameters in healthy people in regions with different types of climate: A meta-analysis, Geofizicheskie Protsessy i Biosfera (Geophysical Processes and Biosphere), 2021, vol. 20, no. 3, pp. 39–60 (in Russian). https://doi.org/10.21455/gpb2021.3-3
English version: Izvestiya, Atmospheric and Oceanic Physics, 2021, vol. 57, iss. 10. ISSN: 0001-4338 (Print), 1555-628X (Online). https://link.springer.com/journal/volumesAndIssues/11485